abstract：:Pneumonia is a major direct cause of death in the elderly. Although aspiration based on a reduced cough reflex is one of the causes of pneumonia in the elderly, there are few studies of angiotensin-I converting enzyme inhibitors (ACE inhibitors), which are antihypertensive drugs that induce cough, as a factor influenc...

journal_title：American journal of hypertension

authors： Okaishi K,Morimoto S,Fukuo K,Niinobu T,Hata S,Onishi T,Ogihara T

更新日期：1999-08-01 00:00:00

abstract：:Antioxidant protection provided by different doses of alpha-tocopherol was compared by determining nitric oxide synthase (NOS) activity in blood vessels of spontaneously hypertensive rats (SHR) treated with alpha-tocopherol. SHR were divided into four groups namely hypertensive control (C), treatment with 17 mg of alp...

journal_title：American journal of hypertension

authors： Newaz MA,Nawal NN,Rohaizan CH,Muslim N,Gapor A

更新日期：1999-08-01 00:00:00

abstract：:The hypertensive transgenic rat model TGR(mRen2)27 has been used to investigate the development of cardiac and vascular hypertrophy in response to two different drug regimes. Cardiac hypertrophy was shown to be related to age and gender with the copy number of mouse renin transgenes having an additive effect. A simila...

journal_title：American journal of hypertension

authors： Brosnan MJ,Devlin AM,Clark JS,Mullins JJ,Dominiczak AF

更新日期：1999-07-01 00:00:00

abstract：:Solitary kidneys, especially in rats, appear vulnerable to develop functional and structural damage. However, differences in susceptibility exist between strains. It is not clear whether this is intrinsic to the kidney or due to environmental factors. Therefore, the aim of the present study was to investigate possible...

journal_title：American journal of hypertension

authors： Kouwenhoven EA,van Dokkum RP,Marquet RL,Heemann UW,de Bruin RW,IJzermans JN,Provoost AP

更新日期：1999-06-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is more prevalent in black than white hypertensives, but this difference is greater when identified by electrocardiography (ECG) than by echocardiography. We evaluated the proposal that current ECG criteria for LVH are less specific, and therefore, less useful, in blacks than whites....

journal_title：American journal of hypertension

authors： Chapman JN,Mayet J,Chang CL,Foale RA,Thom SA,Poulter NR

更新日期：1999-05-01 00:00:00

abstract：:Blood pressure is reportedly elevated in the spontaneously hypertensive rat (SHR) neonate, the etiology of which remains unclear. Aberrations in the hypothalamic-pituitary-adrenal axis have been implicated, as it is well accepted that excess corticosteroids are associated with hypertension. We examined aspects of adre...

journal_title：American journal of hypertension

authors： Malee MP,Wu KY

更新日期：1999-05-01 00:00:00

abstract：:The present study evaluated the effects of miconazole, a selective inhibitor of epoxygenase activity, on renal hemodynamics and the pressure-natriuresis response of saline-drinking, uninephrectomized Lyon hypertensive (LH) and Lyon low blood pressure (LL) rats. Infusion of miconazole (final concentration, 1 micromol/L...

journal_title：American journal of hypertension

authors： Messer-Létienne I,Bernard N,Roman RJ,Sassard J,Benzoni D

更新日期：1999-04-01 00:00:00

abstract：:Hyperinsulinemia and dyslipidemia are known to be associated with essential hypertension but their role in pregnancy-induced hypertension remains unclear. We performed a case-control study comparing cholesterol, insulin, and glucose levels in the early third trimester of pregnancy among 31 women who developed pregnanc...

journal_title：American journal of hypertension

authors： Solomon CG,Carroll JS,Okamura K,Graves SW,Seely EW

更新日期：1999-03-01 00:00:00

abstract：:Vasodilation is impaired in various conditions, such as hypercholesterolemia and tobacco use. We evaluated brachial artery flow-mediated vasodilation (FMD) after blood pressure (BP) cuff occlusion using high-resolution B-mode ultrasound in 20 alcoholics, without any coexisting conditions such as smoking, hypertension,...

journal_title：American journal of hypertension

authors： Maiorano G,Bartolomucci F,Contursi V,Minenna FS,Di Mise R,Palasciano A,Allegrini B,Amoruso M,Kozàkovà M

更新日期：1999-02-01 00:00:00

abstract：:This study was undertaken to examine whether prostaglandin (PG) inhibition with indomethacin interferes with angiotensin II receptor blockade (losartan) during treatment for arterial hypertension. In a double-blind crossover design 10 patients with essential arterial hypertension and treated with losartan were randomi...

journal_title：American journal of hypertension

authors： Olsen ME,Thomsen T,Hassager C,Ibsen H,Dige-Petersen H

更新日期：1999-02-01 00:00:00

abstract：:The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). We investigated whether treatment with an angiotensin II (ANGII) subtype-1 receptor antagonist delays the onset of NIDDM and attenuates diabetic nephropathy in the OLETF rat. OLETF rats fed a re...

journal_title：American journal of hypertension

authors： Uehara Y,Hirawa N,Kawabata Y,Numabe A,Gomi T,Ikeda T,Omata M

更新日期：1999-01-01 00:00:00

abstract：:Galanin is a 29-amino acid peptide and widely distributed in the brain, although its significance in the control of neural activities is undefined. In the present study, we describe the effects of galanin on the electrically evoked release of dopamine in the rat central nervous system. In addition, to elucidate a poss...

journal_title：American journal of hypertension

authors： Tsuda K,Tsuda S,Nishio I,Masuyama Y,Goldstein M

更新日期：1998-12-01 00:00:00

abstract：:The independent and combined effects of aerobic exercise training (AEX) and weight loss (WL) on blood pressure (BP) and oral glucose tolerance were studied in 97 nondiabetic, sedentary, older men. The men were assigned to either a WL (n = 31), AEX (n = 35), AEX+WL (n = 20) intervention, or to a control (CON) group (n ...

journal_title：American journal of hypertension

authors： Dengel DR,Galecki AT,Hagberg JM,Pratley RE

更新日期：1998-12-01 00:00:00

abstract：:To elucidate whether postprandial hypotension (PPH) is associated with any diurnal change of blood pressure, ambulatory blood pressure monitoring was performed on 121 hospitalized essential hypertensive patients who received standardized meals. Postprandial change in blood pressure was defined as the difference betwee...

journal_title：American journal of hypertension

authors： Kohara K,Uemura K,Takata Y,Okura T,Kitami Y,Hiwada K

更新日期：1998-11-01 00:00:00

abstract：:Hypertension is a common finding among obstructive sleep apnea (OSA) patients, and is thought to be caused by sympathetic hyperactivity. The present study compares the contributions of the respiratory disturbance index (RDI) as a reflection of sleep fragmentation, and the magnitude of oxygen desaturation, to sympathet...

journal_title：American journal of hypertension

authors： Peled N,Greenberg A,Pillar G,Zinder O,Levi N,Lavie P

更新日期：1998-11-01 00:00:00

abstract：:The importance of the level to which blood pressure is reduced becomes increasingly important when one considers preservation of renal function. It is clear that three major subsets of patients emerge as requiring levels of blood pressure control of < 130/85 mm Hg to preserve renal function. Such individuals include b...

journal_title：American journal of hypertension

authors： Bakris GL

更新日期：1998-10-01 00:00:00

abstract：:The purpose of this study was to investigate whether acute hyperinsulinemia induces selective hemodynamic effects in the mesenteric, renal, and iliac vascular beds, and to determine whether nitric oxide (NO) plays a role in the regulation of blood flow and mean arterial pressure (MAP) during acute hyperinsulinism. In ...

journal_title：American journal of hypertension

authors： Villa E,García-Robles R,Romero JC

更新日期：1998-10-01 00:00:00

abstract：:Hormone replacement therapy (HRT, estrogen plus progestagen) in postmenopausal women has beneficial effects on the cardiovascular system. However, effects on blood pressure, determined with office measurements, remain controversial. We studied the effects of HRT in 29 healthy normotensive postmenopausal women (mean ag...

journal_title：American journal of hypertension

authors： van Ittersum FJ,van Baal WM,Kenemans P,Mijatovic V,Donker AJ,van der Mooren MJ,Stehouwer CD

更新日期：1998-10-01 00:00:00

abstract：:Insulin resistance and hypertension, as well as dyslipidemia, frequently cooccur. Evidence that nitric oxide (NO) plays a crucial role in the long-term regulation of systolic blood pressure led us to examine whether enhanced vasoconstriction and hypertension induced by NO synthase inhibitor could lead to insulin and l...

journal_title：American journal of hypertension

authors： Erlich Y,Rosenthal T

更新日期：1998-09-01 00:00:00

abstract：:It has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension. On the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established. The aim of this study is to clarify th...

journal_title：American journal of hypertension

authors： Miyazaki Y,Hirata A,Murakami H,Fukuoka M,Agata J,Higashiura K,Masuda A,Ura N,Shimamoto K

更新日期：1998-09-01 00:00:00

abstract：:Intranasal administration of some peptides has been shown to directly influence central nervous functions, thus pointing to a nose-brain pathway for these substances in humans. The present study investigated whether intranasal administration of angiotensin II (ANG II) affects central nervous functions of cardiovascula...

journal_title：American journal of hypertension

authors： Derad I,Willeke K,Pietrowsky R,Born J,Fehm HL

更新日期：1998-08-01 00:00:00

abstract：:Recently, an endogenous digitalis-like factor (EDLF) was shown to be stimulated in corticotropin (ACTH) hypertension in the rat. We have shown that mammalian plasma contains a vasoconstrictor Na,K-ATPase inhibitor, which cross-reacts with an antibody to amphibian EDLF, marinobufagenin. In the present experiment, the e...

journal_title：American journal of hypertension

authors： Fedorova OV,Anderson DE,Bagrov AY

更新日期：1998-07-01 00:00:00

abstract：:The purpose of this study was to determine plasma and tissue endothelin-1 (ET-1)-like immunoreactivity in a new rodent model of spontaneous hypertension. Plasma and tissues were procured from pentobarbital-anesthetized 16- to 18-week-old male hamsters with spontaneous hypertension and genetically/age-matched normotens...

journal_title：American journal of hypertension

authors： Gulati A,Artwohl JE,Kumar A,Gao XP,Rubinstein I

更新日期：1998-07-01 00:00:00

abstract：:Further improvement in blood pressure control at the population level will result from dealing with hard-to-solve problems, such as access to care, long-term management of a chronic disease, and societal influences on lifestyle. Additional knowledge and experimental data are needed, reinforced by clear public health c...

journal_title：American journal of hypertension

authors： Lang T

更新日期：1998-07-01 00:00:00

abstract：:Cocaine causes acute hypertension by blocking catecholamine reuptake. There is evidence that it also impairs the peripheral endothelial nitric oxide system, which is normally vasodilatory. We further explored the role of nitric oxide in cocaine-induced vasoconstriction in anesthetized rats, and in vitro by using isola...

journal_title：American journal of hypertension

authors： Mo W,Singh AK,Arruda JA,Dunea G

更新日期：1998-06-01 00:00:00

abstract：:The stimulation of autocrine and paracrine factors such as basic fibroblast- (bFGF) and platelet-derived (PDGF) growth factors mediates many of the growth-promoting actions of angiotensin II. The aim of this study was to evaluate the effect of chronic AT1-receptor blockade on plasma endothelin-1 (ET-1) and growth fact...

journal_title：American journal of hypertension

authors： Cottone S,Vadalà A,Vella MC,Nardi E,Mulé G,Contorno A,Riccobene R,Cerasola G

更新日期：1998-05-01 00:00:00

abstract：:The process whereby a physician explains to the ill patient what has gone wrong and what can be done about it can be taught and evaluated by simulated patients (SPIs). This study was designed to determine whether a training experience in educating a diabetic SPI improves subsequent performance with a hypertensive SPI....

journal_title：American journal of hypertension

authors： Zweifler AJ,Sisson JC,Wolf FM,Trabin NL,Dicken LL,Gruppen LD,Grum CM,Baum KD

更新日期：1998-05-01 00:00:00

abstract：:Endothelin-1, discovered in 1988, is a 21-amino-acid peptide and currently the most potent vasoconstrictor and pressor substance known. Generated by vascular endothelial cells in response to a variety of chemical and mechanical signals, endothelin-1 is known to potentiate the actions of other vasoconstrictor substance...

journal_title：American journal of hypertension

authors： Webb DJ,Strachan FE

更新日期：1998-04-01 00:00:00

abstract：:This study was designed to analyze the cardiac effects of aging and of hypertension in patients with essential hypertension and with or without left ventricular hypertrophy (LVH). Thirty-one patients <55 years old and 66 patients >64 years old with essential hypertension were divided according to the presence or absen...

journal_title：American journal of hypertension

authors： Grodzicki T,Michalewicz L,Messerli FH

更新日期：1998-04-01 00:00:00

abstract：:The results of ambulatory blood pressure monitoring (ABPM) in children after kidney transplant were analyzed to ascertain any alteration in circadian BP profile, degree of hypertension, and efficacy of therapy. The data were also compared with casual BP data and left ventricular mass index (LVMI). We have examined 30 ...

journal_title：American journal of hypertension

authors： Calzolari A,Giordano U,Matteucci MC,Pastore E,Turchetta A,Rizzoni G,Alpert B

更新日期：1998-04-01 00:00:00

abstract：:The objective of this study was to test the relationship between neurologic and microvascular complications of type 1 diabetes mellitus. It was hypothesized that the mechanisms operative in autonomic dysfunction seen in diabetic patients with microangiopathy play a role in the rapidity of progression to renal failure....

journal_title：American journal of hypertension

authors： Weinrauch LA,Kennedy FP,Gleason RE,Keough J,D'Elia JA

更新日期：1998-03-01 00:00:00

abstract：:Thromboembolic complications such as ischemic stroke and myocardial infarction are significantly more frequent in patients with arterial hypertension. From the available intervention studies, it appears that pharmacologic treatment of hypertension-at least with diuretics and beta-blockers-may more effectively protect ...

journal_title：American journal of hypertension

authors： Lottermoser K,Weisser B,Hertfelder HJ,Wöstmann B,Vetter H,Düsing R

更新日期：1998-03-01 00:00:00

abstract：:Conflicting reports exist as to whether air traffic controllers (ATC) have an increase in blood pressure (BP) and prevalence of hypertension because of the stressful nature of their job. We have addressed the issue in male ATC working at the Linate airport of Milan. A total of 80 ATC participated, and the 24 h blood p...

journal_title：American journal of hypertension

authors： Sega R,Cesana G,Costa G,Ferrario M,Bombelli M,Mancia G

更新日期：1998-02-01 00:00:00

abstract：:Hypertension is the most ubiquitous risk factor for developing cardiovascular disease, which is the leading cause of death in the United States. Results from clinical trials have established the benefit of antihypertensive therapy in preventing the morbidity and mortality associated with high blood pressure, including...

journal_title：American journal of hypertension

authors： Black HR

更新日期：1998-01-01 00:00:00

abstract：:The present study evaluates the growth promoting effect of insulin on the proliferative activity of cells from rat mesenteric arteries in culture in order to test the hypothesis that insulin may play a pathogenetic role in the hypertrophy of resistance vessels. The proliferative effect of insulin was studied in cultur...

journal_title：American journal of hypertension

authors： Cruzado M,Risler N,Castro C,Ortiz A,Rüttler ME

更新日期：1998-01-01 00:00:00

abstract：:This study was designed to clarify the relationship between the antihypertensive effects of the calcium antagonist nilvadipine, and circadian changes in blood pressure. Based on measurements using an ambulatory blood pressure monitoring system (ABPM), 17 outpatients with untreated essential hypertension were divided i...

journal_title：American journal of hypertension

authors： Yoshikawa H,Ohta A,Kasamatsu K,Ueno C,Funai H,Kuse S,Satani O,Nakamura N,Fukuda K,Hano T,Ueno Y,Nishio I,Iseki Y

更新日期：1998-01-01 00:00:00

abstract：:Angiotension converting enzyme (ACE) inhibitors and beta-blockers have been reported to possess disparate effects on insulin sensitivity. The aim of this study was to study the effects of the selective beta-1 blocker bisoprolol and of the ACE inhibitor captopril on cellular insulin action in hypertensive individuals. ...

journal_title：American journal of hypertension

authors： Dominguez LJ,Barbagallo M,Jacober SJ,Jacobs DB,Sowers JR

更新日期：1997-12-01 00:00:00

abstract：:To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ...

journal_title：American journal of hypertension

authors： Resnick LM,Bardicef O,Altura BT,Alderman MH,Altura BM

更新日期：1997-12-01 00:00:00

abstract：:Increased insulinemic response to an oral glucose load has been demonstrated in Dahl salt-sensitive hypertensive rats. To determine whether this abnormality is mediated at the level of the insulin receptor, we compared insulin receptor binding and mRNA levels in tissues of Dahl salt-sensitive rats (DS) and in their no...

journal_title：American journal of hypertension

authors： Sechi LA,Griffin CA,Zingaro L,Catena C,De Carli S,Schambelan M,Bartoli E

更新日期：1997-11-01 00:00:00

abstract：:Migration of monocytes into the subendothelial space of the aorta has been considered to be an important event in the development of atherosclerosis. Because hypertension is commonly associated with atherosclerosis, we studied the effect of applied pressure on the migration of monocytes. Direct applied pressure increa...

journal_title：American journal of hypertension

authors： Singhal PC,Sagar P,Gupta S,Arya M,Gupta M,Prasad A,Loona R,Sharma P,Mattana J

更新日期：1997-11-01 00:00:00